Actinic Keratosis and Cutaneous Squamous Cell Carcinoma

Actinic Keratosis and Squamous Cell Carcinoma

Actinic keratosis and squamous cell carcinoma.

Actinic keratosis is a common skin disorder in elderly patients with fair complexions. It is caused by exposure to ultraviolet light. If left untreated, actinic keratosis may progress to squamous cell carcinoma. The metastatic potential and prognosis vary with the type and location of the lesion. Several approaches to treatment are available, including local destruction, excisional surgery, Moh...

Actinic Keratosis and Squamous Cell Carcinoma

Genomic instability in human actinic keratosis and squamous cell carcinoma

OBJECTIVE To compare the repetitive DNA patterns of human actinic keratoses and squamous cell carcinomas to determine the genetic alterations that are associated with malignant transformation. INTRODUCTION Cancer cells are prone to genomic instability, which is often due to DNA polymerase slippage during the replication of repetitive DNA and to mutations in the DNA repair genes. The progressi...

A prospective clinical trial to assess lapatinib effects on cutaneous squamous cell carcinoma and actinic keratosis

BACKGROUND Antiepidermal growth factor receptor (EGFR)-targeted therapy is widely used in many epithelial cancer types. We investigated lapatinib effects on cutaneous squamous cell carcinoma (cSCC) scheduled for resection and in coexisting precursor lesions (actinic keratosis (AK) and Bowen's disease (BD)) in a phase 2 mode of action clinical trial including a histological workup of the cSCC. ...